In the pursuit of understanding the role of Myosin, a class of motor proteins, we developed first-in-class molecular nanomotor drugs

Molecular motors are fundamental to a wide range of diseases, including cancers, vascular diseases, microbial infections, fibrosis, neurodegeneration, and psychiatric disorders. For example, nonmuscle myosin IIA regulates cell movement by physically moving and reshaping the actin cytoskeleton and nonmuscle myosin IIB regulates cell division.

This approach targets a previously untapped superfamily of drug targets that serve critical roles in cell movement, growth, division, and transport.

allows tumor cells to change shape and invade healthy tissue, supporting metastasis.
is the convergent point for cell division, promoting tumor cell proliferation.

To treat cancer, we developed a family of dual inhibitors of NMIIA and NMIIIB to simultaneously block tumor invasion and proliferation