Technology
In the pursuit of understanding the role of Myosin, a class of motor proteins, we developed first-in-class molecular nanomotor drugs
Molecular motors are fundamental to a wide range of diseases, including cancers, vascular diseases, microbial infections, fibrosis, neurodegeneration, and psychiatric disorders. For example, nonmuscle myosin IIA regulates cell movement by physically moving and reshaping the actin cytoskeleton and nonmuscle myosin IIB regulates cell division.
This approach targets a previously untapped superfamily of drug targets that serve critical roles in cell movement, growth, division, and transport.
NMIIA
allows tumor cells to change shape and invade healthy tissue, supporting metastasis.
NMIIB
is the convergent point for cell division, promoting tumor cell proliferation.
